The progestin implant, Implanon, introduced in 1999, has been replaced by an updated version called Nexplanon. The new implant contains the same medication as its predecessor.

The progestin implant is a soft, flexible polymer about the size of a match stick that is inserted subdermally in the upper arm. The implant works by releasing 68 mg of progestin etonogesterel slowly over a 3-year period. After 3 years, the device no longer releases enough hormone to prevent pregnancy and should be removed.

How does Nexplanon differ from Implanon? There are only two differences:

1. Nexplanon is radiopaque, so it shows up easily on x-rays. Faced with difficult insertion or removal, providers can now use an x-ray to locate the device.
2. The new implant has a modified applicator. This reduces the risk of needle stick injury and deep placement. It also allows for one-handed insertion.

Clinicians already trained in progestin implant insertion need only watch a refresher video before inserting the new device. Providers who haven’t been trained can take a 3-hour course. Find information about both types of trainings here.

The new implant’s side effects are identical to those of its predecessor, and anticipatory guidance remains important. The implant causes irregular bleeding. Many women have unpredictable spotting which lasts until the implant is removed. The implant is 99.9% effective at preventing pregnancy for up to 3 years. It’s a great choice for women who want long-term, reversible contraception, and who prefer not to get an IUD.

We appreciate your feedback! Please write us at pearls@reproductiveaccess.org with any questions, comments or additional resources to add to our list.

Helpful Resources

Progestin Implant Fact Sheet
Progestin Implant User Guide
Medical Eligibility for Initiating Contraception
Nexplanon Training

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The Reproductive Health Access Project does not accept funding from pharmaceutical companies. We do not promote specific brands of medication or contraception. The information in the Contraceptive Pearls is unbiased, based on science alone.